2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endothelin-Converting Enzyme (ECE)

Endothelin-Converting Enzyme (ECE)

Endothelin-Converting Enzyme; ECE

Endothelin-Converting Enzyme (ECE) belongs to the M13 family of zinc metalloproteases and is a membrane-bound endopeptidase. ECE preferentially cleaves on the amino side of hydrophobic amino acid residues, with the ability to precisely hydrolyze a series of biologically inactive intermediates known as big endothelins (big ET-1, -2, and -3) at the Trp21-Val/Ile22 bond, thereby forming biologically active endothelin-1 (ET-1), endothelin-2 (ET-2), and endothelin-3 (ET-3). These endothelins play a pivotal role in blood flow regulation.
The ECE family comprises three members: ECE-1, ECE-2, and ECE-3, each encoded by a distinct gene. Unlike other family members, ECE-3 (also known as the Kell blood group antigen) is predominantly found in red blood cell tissue and is not expressed in the central nervous system (CNS).
ECE is commonly used in research on cardiovascular diseases (such as hypertension) and Alzheimer's disease[1][2].

Endothelin-Converting Enzyme (ECE) Isoform Specific Products:

Endothelin-Converting Enzyme (ECE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-120148A
    SM19712
    		Inhibitor 99.0%
    SM19712 serves as an inhibitor of the nonpeptide endothelin converting enzyme.
    SM19712
  • HY-178732
    AB-22
    		Inhibitor
    AB-22, a vinyl sulfate compound, is an orally active antifungal agent. AB-22 inhibits hyphal growth and biofilm initiation by inhibiting the gene expression of ALS3, HWP1, and ECE1 in Candida albicans SC5314 cells. AB-22 can be used for the research of infrction, such as systemic candidiasis.
    AB-22
  • HY-107762
    CGS35066
    		Inhibitor
    CGS35066 is a potent and selective aminophosphonate inhibitor of endothelin-converting enzyme-1 (ECE-1). CGS 35066 inhibits the activity of human ECE-1 and rat kidney neutral endopeptidase 24.11 (NEP) in vitro with IC50 values of 22 nM and 2.3 μM, respectively.
    CGS35066
  • HY-119545
    PD159790
    		Inhibitor
    PD159790 is a selective endothelin-converting enzyme-1 (ECE-1) inhibitor, with an EC50 of 28.1 μM.
    PD159790
  • HY-14474
    CGS 26303
    		Inhibitor
    CGS 26303 is an endothelin-converting enzyme (ECE) inhibitor. CGS 26303 increases the expression of endothelin-converting enzyme-1 in endothelial cells. CGS 26303 attenuates cerebral vasospasm in a rabbit subarachnoid hemorrhage model. CGS 26303 improves birth survival and alleviates pulmonary hypoplasia in newborn rats in a rat model of congenital diaphragmatic hernia. CGS 26303 can be used for research on cardiovascular and cerebrovascular diseases and congenital diaphragmatic hernia.
    CGS 26303
  • HY-120148
    SM19712 free acid
    SM19712 (free acid) is an endothelin-converting enzyme-1-related compound that affects corticotropin-releasing factor receptor 1 (CRF1).
    SM19712 free acid
Endothelin-Converting Enzyme (ECE) Isoform Comparison

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